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Maude Abbott Lecture 2020: Killer on the Loose? Precursor Escape and Ovarian Carcinogenesis

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Original release date: April 14, 2020 
Access to this course expires on:  March 3, 2023 at 11:59 PM Pacific Time
CME .75

Course Description
Dr. Christopher Crum traces the time-line of ovarian cancer research, highlighting the impact of pathology on the quest for effective ovarian cancer prevention. Integral to the quest has been the search for truths that quietly await recognition in a tissue section under a light microscope. During this search the pathologist must continually question his or her assumptions and test emerging hypotheses, while striving for meaningful discovery.

Target Audience
Practicing academic and community pathologists, and pathologists-in-training

Learning Objectives
Upon completion of this educational activity, learners will be able to:
  • Recite the pathologic characteristics and pathogenetic significance of the pseudo-endometrioid solid and transitional patterns (A.K.A. SET) of high-grade serous carcinoma.
  • Describe two pathways to intra-peritoneal high-grade serous carcinoma originating in the distal fallopian tube.
  • Understand the role of “precursor escape” to both endometrioid and serous cancer, its frequency, and its impact on early detection and prevention.

Continuing Medical Education
The United States and Canadian Academy of Pathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The United States and Canadian Academy of Pathology designates this enduring material for a maximum of .75 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The faculty, committee members, and staff who are in position to control the content of this activity are required to disclose to USCAP and to learners any relevant financial relationship(s) of the individual or spouse/partner that have occurred within the last 12 months with any commercial interest(s) whose products or services are related to the CME content. USCAP has reviewed all disclosures and resolved or managed all identified conflicts of interest, as applicable.

The following faculty reported relevant financial relationships: Christopher P. Crum, MD, Consultant, Freyja Health Care

The following planners reported financial relationships:
Ashley Cimino-Mathews: Grant or Research Support: Bristol-Myers Squibb
Yuri Fedoriw: Consultant: Alexion Pharmaceuticals
Jason Hornick: Consultant: Eli Lilly, Epizyme
Anna Marie Mulligan: Speaker: AstraZeneca; Consultant: Roche
Lynette Sholl: Advisory Board Member: LOXO Oncology; Speaker: AstraZeneca; Grant or Research Support: Roche/Genentech

The following planners reported no relevant financial relationships:
Zubair Baloch, Steven Billings, Daniel Brat, James Cook, Sarah Dry, William Faquin, Karen Fritchie, L. Priya Kunju, Laura Lamps, Rish Pai, David Papke, Jr., Vinita Parkash, Carlos Parra-Herran, Anil Parwani, Rajiv Patel, Deepa Patil, Raja Seethala, Ilan Weinreb, Rhonda Yantiss, Nicholas Zoumberos

USCAP staff associated with the development of content for this activity reported no relevant financial relationships.

To earn CME credit, all learners must complete the evaluation. View and print your certificate by clicking here.

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