Skip to main content

Mesenchymal Tumors: From Head to Toe (and Everything in Between)

Original release date:
February 17, 2022
Access to this course expires on:  December 13, 2024 at 11:59 PM Pacific Time
CME 17

Course Description
Mesenchymal tumors are inherently diagnostically challenging, but a significant practice gap in their interpretation has developed as new entities and genetic abnormalities have emerged. Diagnostic challenges are associated with distinguishing benign spindle cell proliferations from high grade sarcoma due to histologic and immunohistochemical overlap. In addition to benign and malignant categories, contemporary classification of mesenchymal neoplasms emphasizes lesions with intermediate biologic potential, including those that are locally aggressive or rarely metastasize. There are circumstances in which pathologists can render only descriptive diagnoses without precise classification. New discoveries in molecular genetics have clarified some of these problematic lesions. Furthermore, there are newly described entities that practicing pathologists should be aware of so that tumors are appropriately diagnosed and optimally treated. This course, presented by expert mentors and educators, explores a comprehensive panorama of lesions and anatomic sites.

Target Audience
Practicing academic and community pathologists, and pathologists-in-training

Learning Objectives
Upon completion of this educational activity, learners will be able to:
  • Recognize common and problematic mesenchymal lesions of different anatomic sites
  • Become familiar with recently described diagnostic entities
  • Design a panel of ancillary testing that aids in the diagnosis of mesenchymal tumors
  • Avoid pitfalls caused by erroneous interpretation of immunohistochemical stains
  • Understand the diagnostic criteria for malignancy and for the classification of mesenchymal neoplasms

Continuing Medical Education
The United States and Canadian Academy of Pathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The United States and Canadian Academy of Pathology designates this enduring material for a maximum of 17 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


The faculty, committee members, and staff who are in position to control the content of this activity are required to disclose to USCAP and to learners any financial relationship(s) that have occurred within the last 24 months with any commercial interest(s) whose products or services are related to the CME content. USCAP has reviewed all disclosures and mitigated all identified conflicts of interest, as applicable.

The following faculty reported no relevant financial relationships: Andre Pinto, MD, Edi Brogi, MD, PhD, Darcy A. Kerr, MD, Gregory Y. Lauwers, MD, Andrew Eric Rosenberg, MD, Bruce M. Wenig, MD

The following IM Coordinator who planned and reviewed content for this activity reported no relevant financial relationships: Elizabeth G. Demicco, MD, PhD

USCAP staff associated with the development of content for this activity reported no relevant financial relationships.

To earn CME credit, all learners must complete the evaluation. View and print your certificate by clicking here.

Buy the entire course and get a great discount! Not A Member? Click Here